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    Title A national treasure 'Antrodia cinnamomea' in Taiwan, Revolutionary technology to cultivate its mycelium & R&D for Hepatoprotection and Immunomodulation
    Date 2026.08.27 (13:40 - 14:10) | Hall C Seminar room
    Organization Synergybio
    Speaker Leon Hsu, CEO
    Speaker & Lecture Information

    [Brief Introduction of Seminar] 

    A National Treasure "Antrodia cinnamomea" in Taiwan: Revolutionary Technology to Cultivate its Mycelium & R&D for Hepatoprotection and Immunomodulation

     

    Taiwan's legendary 'Forest Ruby' - from traditional remedy to global clinical evidence

     

    Antrodia cinnamomea (niu-chang-chih) is a rare medicinal fungus endemic to Taiwan, growing exclusively on the heartwood of the endangered Cinnamomum kanehirae tree. Known as the "Forest Ruby" for its brilliant red fruiting body, it has been revered in traditional medicine for centuries for hepatoprotection, anti-inflammation, detoxification, hangover relief, and immune enhancement. Wild harvesting has led to near-extinction of natural resources, and the tree species is now legally protected. Antromax® overcomes this supply challenge through solid-state cultivation while delivering superior active compound profiles compared to wild material, enabling standardized, scalable, and sustainable production for global commercial application.

     

    PATENTED FERMENTATION TECHNOLOGY

     

    Greenyn's proprietary adversity-domestication fermentation platform is the technological breakthrough. Unlike conventional liquid fermentation (minimal triterpenoids) or log-cultivation (2-3 years, unsustainable), this platform simulates the fungus's native habitat stress conditions - controlled temperature, humidity, pH, and nutritional stress - triggering robust secondary metabolite production.

     

    Key Metrics: Total triterpenoids exceed 180% of 3-year-old wild fruiting bodies.

    Cultivation Cycle: 3-4 months vs. 2-3 years wild.

    8-Country Patent Family: Taiwan (1543706), USA (US9458421B2), Germany, Japan (5814322/3188254), China (ZL201310432728.7), Malaysia (MY167124A), Korea (10-2125300), and Belgium.

     

    STRONG CLINICAL EVIDENCE & FUNCTIONAL BENEFITS

     

    Hepatoprotection (RCT, Japan): Double-blind, placebo-controlled 12-week trial in 38 sub-healthy adults (ALT 30-51 IU/L) demonstrated significant ALT/AST reduction.

    Chronic Hepatitis B (RCT, China Medical University Hospital): Adjuvant therapy to Entecavir showed enhanced viral suppression and liver enzyme normalization.

    Alcohol Metabolism: Animal studies showed ADH +40%, ALDH +42%, accelerating sobriety by 7 hours.

    Safety Profile: Passed acute toxicity (NOAEL), 90-day sub-chronic, genotoxicity testing (Ames negative), and teratogenicity testing.

    Global Compliance & Certifications: USFDA NDI No. 1170 (world's first), health food certification, SNQ National Quality Mark, ISO 22000, FSSC 22000, GMP, and Halal.

     

    ​[Brief Introduction of Speaker] 

    Dr. Leon Hsu

    CEO & R&D Director, Greenyn Biotechnology (TPEx: 6846)

     

    EDUCATION

    Ph.D. in Food Science and Biotechnology, National Chung Hsing University, Taiwan

    Cross-disciplinary training in molecular biology, food chemistry, and nutraceutical product development  

     

    EXPERIENCE

    CEO & R&D Director, Greenyn Biotechnology (Listed on TPEx: 6846) - leading 150+ professionals

    Transitioned Greenyn from ingredient distributor into a science-driven, publicly listed global innovator exporting to 15+ countries

     

    Full-spectrum R&D pipeline: functional peptide engineering, solid-state fermentation, clinical trials, international regulatory submissions (FDA, EFSA, Japan, Korea, China)

     

    KEY ACHIEVEMENTS

    Invented 10+ proprietary branded ingredients including Insumate (patented bitter melon peptide for blood sugar management), Antromax (world's first FDA NDI Antrodia cinnamomea), Citrusvel and more across metabolic health, hepatoprotection, immunity, and immune health etc.

     

    100+ international patents across 8 countries (US, EU, JP, CN, KR, MY, TW, DE) for functional ingredient compositions, fermentation technologies, and peptide sequences

     

    Published 10+ peer-reviewed international journal papers on functional peptide discovery, clinical validation, and bioactive compound characterization

     

    Awarded 30+ international invention prizes, and National Innovation Award and multiple domestic invention honors

     

    Achieved 2 USFDA-NDI, Received 2 SNQ National Quality Marks, multiple health food functional claims (liver function and immune health), and spearheaded Greenyn's IPO (TPEx: 6846) 

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