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Lipid Nanoparticles (LNPs) are a cornerstone of modern genomic medicine delivery enabling breakthroughs such as rapid mRNA vaccine deployment during COVID-19. Beyond vaccines, LNPs advance gene editing and protein replacement therapies. Formulation parameters are critical for RNA encapsulation, protection and endosomal escape, providing critical potency and safety. Conjugating LNPs to peptides, antibodies, sugars or aptamers enables tissue specific targeting and receptor mediated uptake, reducing off-target effects. Conjugatable lipid anchors define ligand orientation, stability and accessibility – key for targeting efficiency and therapeutic performance.

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[Brief Introduction of Seminar]

In this presentation, we will introduce our recent advances in biodegradable microneedle array patch (MAP) technologies for transdermal drug delivery and biosensing applications. We have developed novel fabrication strategies for biodegradable MAPs capable of delivering recombinant vaccinia virus vectors expressing the SARS-CoV-2 spike protein (rDIs-S) and DENV2C-NS25 (rDIs-DENV2C), demonstrating their potential as next-generation vaccine platforms.

In addition, we have developed porous microneedle-based biosensing platforms that enable the direct integration of sensing elements with paper-based analytical devices. This platform enables rapid, minimally invasive sampling of interstitial fluid (ISF) and electrochemical detection of biomarkers within minutes. Collectively, these technologies expand the functionality of microneedles beyond conventional transdermal drug delivery, providing a versatile platform for continuous health monitoring and point-of-care diagnostics.

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Beomjoon Kim is a Professor at the Institute of Industrial Science (IIS), The University of Tokyo, Japan. He currently serves as Director of LIMMS-KIKO and Director of the Center for Research on Engineering in Medicine and Biology (CREMeB) at IIS. He received his B.E. in Mechanical Design and Production Engineering from Seoul National University, Korea, in 1993, and his M.S. and Ph.D. in Precision Engineering from The University of Tokyo, Japan, in 1995 and 1998, respectively.

He was a CNRS Associate Researcher at LPMO in Besançon, France, and a Researcher at the MESA+ Research Institute, University of Twente, the Netherlands, from 1998 to 2000. He joined The University of Tokyo in 2000 as an Associate Professor and has been serving as a Professor since 2013. He also served as Co-Director of the CIRMM/CNRS Paris Office from 2001 to 2003.

His research focuses on biosensors for portable point-of-care diagnostics, self-powered energy-harvestig microsensors, smart monitoring systems, and dissolvable microneedle-based transdermal drug delivery systems. In recent years, he has concentrated on the development of next-generation transdermal drug delivery technologies using dissolvable microneedle patches.

To date, he has authored 134 peer-reviewed journal articles, 278 international conference papers, 237 domestic conference papers, and numerous patents and book publications.

A Case Study on Microneedle Vaccine Development Using High-Speed, High Drug-Loading Coating Technology​

A Case Study on Drug Development Using the Microneedle Array Patch (MAP) Platform​

A Multilayer Microneedle Platform for the Stable Delivery of Anti-Diabetic and Anti-Obesity Therapeutics​

Characteristics and Application Development Strategies by MAPs Platform Technology ​

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Introduction to a Technology for Functional Enhancement and Discovery of Novel Natural Product-Based Materials through Structural Bioconversion Using Indigenous Microorganisms​

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- Affilliation: National Institute of Biological Resources

- Education: 2008. phD. The University of Tokyo

- Experience: 2014~present. NIBR

- Research Field: Discovery of bio-active compound 

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Microorganisms are an important source of structurally diverse bioactive compounds with potential applications in anticancer drug development. This patented technology relates to novel microbe-derived peptides that were isolated, structurally characterized, and chemically synthesized. Using the MTT assay, the cell proliferation-inhibitory activity of these synthetic peptides was evaluated against multiple human cancer cell lines. The peptides exhibited varying degrees of cell proliferation-inhibitory activity across the tested cancer cell lines, with particularly pronounced effects observed in A549 human lung cancer cells. Based on these results, A549 cells were selected for further investigation of the underlying molecular mechanisms. Apoptosis and cell-cycle analyses supported the involvement of the mitochondria-mediated intrinsic apoptotic pathway in peptide-induced cell death. Molecular modeling was subsequently performed to identify potential target proteins associated with this activity. Further studies are needed to clarify the interactions between the peptides and these candidate targets. The patented peptides are chemically synthesizable and have potential as anticancer lead compounds.​

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Education : ('22) Ph.D. in Biotechnology, Pukyong National University, 2022

Major Experience : ('19-present) Associate Researcher, Prokaryotic Research Division, Nakdonggang National Institute of Biological Resources

Research Areas : Discovery of valuable microbial metabolites, molecular modeling, and structure-guided engineering of bioactive compounds and enzymes

Current Research : Investigation of interactions between microbe-derived compounds and their target proteins, and structure-guided engineering of enzyme function

Selected Achievements : 13 SCI(E)-indexed publications, 14 patents, and 2 technology transfers 

Overview of Health Promotion and Environmental Improvement Technologies Based on Island and Coastal Biological Resources

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Current Affiliation: Honam National Institute of Biological Resources (HNIBR- Highest Degree: Ph.D. in Science, Hanyang University (2017)

- Professional Experience:

2018~2021: Nakdonggang National Institute of Biological Resources (NNIBR)2021~Present: Honam National Institute of Biological Resources (HNIBR)